DAPSONE TREATMENT OF LEPROSY

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چکیده

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Malaria, leprosy and dapsone.

Although the preventive action of dapsone against P. falciparum malaria was known for many years, there was no report about the incidence of P. falciparum malaria in leprosy patients treated with dapsone, especially from areas of Southeast Asia where both leprosy and malaria are endemic. Therefore, two clinic-based malaria surveys were undertaken at a gap of 12 years, comprising 506 lepromatous...

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Treatment of paucibacillary leprosy patients with dapsone and rifampicin.

Dapsone resistance is found worldwide (1,2) and resistance to other available drugs such as clofazamine (3) and rifampicin (4) also occurs. It is known that paucibacillary leprosy patients harbour <106 bacilli (5). However, the treatment of paucibacillary leprosy is of long duration. It is psychologically undesirable for a symptom-free, paucibacillary patient to receive therapy for a long perio...

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Dapsone agranulocytosis in a leprosy patient.

Dapsone-induced agranulocytosis is a rare adverse effect. There are various reports of agranulocytosis in patients treated with dapsone for malaria prophylaxis and other dermatological diseases. However, this adverse reaction in leprosy is not often encountered. We describe agranulocytosis in a young patient who was taking dapsone (100 mg) for borderline-tuberculoid leprosy in a rural environment.

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Low dose dapsone therapy in lepromatous leprosy.

U n der the conditions of this s tudy, dapsone in d oses of 5 mg and 10 mg daily when ad ministered to p atients with lepromat ous leprosy is an ineffe ctive therapy in terms of killing and elimin ation of My co. leprae from human skin and b one marrow . A real danger of facili tating the emergence of resistant bacilli exists . Therefore , un til there is more evidence from long term therapeuti...

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Trial of high dosages of dapsone in the treatment of tuberculoid leprosy.

Two groups, each of 1 00 patients suffering from tuberculoid leprosy, were treated with different dosages of dapsone, the control group being given a conservative dosage of the drug and the study group a high dosage ( 1 200 mg weekly) . The patients in the high-dosage group showed more rapid regression of the disease , a lower incidence of relapse and early regression of the tingling, enlargeme...

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ژورنال

عنوان ژورنال: Leprosy Review

سال: 1952

ISSN: 0305-7518

DOI: 10.5935/0305-7518.19520013